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It is an intramuscular injection and the steroid is not much active and has low bioavailability when taken by mouth. When taken orally it acts on skin directly, and when taken by mouth it affects blood vessels. Some patients in the drug-use group used the cream to treat acne, but the cream was less effective than hydroquinone, a common acne medication. Some patients used the cream to treat seborrheic dermatitis, but the cream was less effective than piroxicam, another common acne medication. The researchers say the treatment is particularly useful in those who have been treated with oral medications, or who suffer from multiple types of acne. "We have found that the active ingredients in this treatment can be used more effectively when combined with other acne treatments," Dr. Heimberg explains. "Using this combination of cream and topical prescription medications means a reduction in the number of sessions and the need to take a larger supply of medication." For now, patients can use the product to treat active acne lesions or to relieve inflammation in other types of skin, though the researchers say that additional research would be necessary to test this approach more precisely. Additional support for the study came from the National Science Foundation. Researchers from University Hospitals, Boston and Massachusetts General Hospital contributed to the study. There are a series of clinical trials to determine the most effective acne treatments for the treatment of acne, which will be finished at the end of June. Related Article: